???? ?????? ?? ???? ???? ?????? ????? ???? ?? ???? ???? ???? ??? ??????? ??? ??? ???? ????? ??????? ???? ???? ??????.???? ????? ??? ??? ????? ?? ?? ??????? ???????: ????? ????? ? ?????, ??? ??? ????? ?? ????? ?? ??????, ??? ?????.On typical, age larger than sixty five years was linked to a rise in oxymorphone AUC and Cmax. Initiate dosing with OPAN